Quinine

WHY is this medicine prescribed?

Quinine is used alone or with other medications to treat malaria (a serious or life-threatening illness that is spread by mosquitos in certain parts of the world). Quinine should not be used to prevent malaria. Quinine is in a class of medications called antimalarials. It works by killing the organisms that cause malaria.

HOW should this medicine be used?

Quinine comes as a capsule to take by mouth. It usually is taken with food three times a day (every 8 hours) for 3 to 7 days. Take quinine at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take quinine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not open, chew, or crush them. Quinine has a bitter taste.

You should begin to feel better during the first 1-2 days of your treatment. Call your doctor if your symptoms do not improve or if they get worse. Also call your doctor if you have a fever soon after you finish your treatment. This could be a sign that you are experiencing a second episode of malaria.

Take quinine until you finish the prescription, even if you feel better. If you stop taking quinine too soon or if you skip doses, your infection may not be completely treated and the organisms may become resistant to antimalarials.

Are there OTHER USES for this medicine?

Quinine is also sometimes used to treat babesiosis (a serious or life-threatening illness that is transmitted from animals to humans by ticks). Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What SPECIAL PRECAUTIONS should I follow?

Before taking quinine,

• tell your doctor and pharmacist if you are allergic to quinine, quinidine, mefloquine (Lariam), any other medications, or any of the ingredients in quinine capsules. Ask your doctor or pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while taking quinine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• do not take antacids that contain magnesium or aluminum (Alternagel, Amphogel, Alu-cap, Alu-tab, Basaljel, Gaviscon, Maalox, Milk of Magnesia, or Mylanta) at the same time as you take quinine.Talk to your doctor or pharmacist about how long you should wait between taking this type of antacid and taking quinine.
• the following nonprescription products may interact with quinine: cimetidine (Tagamet); ranitidine (Pepcid AC); sodium bicarbonate (in baking soda); dextromethorphan. Be sure to let your doctor and pharmacist know that you are taking these medications before you start taking quinine. Do not start any of these medications while taking quinine without discussing with your healthcare provider.
• tell your doctor if you or anyone in your family has or has ever had a prolonged QT interval (a rare heart problem that may cause fainting or irregular heartbeat), an abnormal electrocardiogram (ECG; a test that measures the electrical activity of the heart), and if you have or have ever had G-6-PD deficiency (an inherited blood disease), or if you have or have ever had myasthenia gravis (MG; condition that causes weakness of certain muscles), or optic neuritis (inflammation of the optic nerve that may cause sudden changes in vision). Also tell your doctor if you have ever had a serious reaction, especially a bleeding problem or problems with your blood after taking quinine in the past. Your doctor will probably tell you not to take quinine.
• tell your doctor if you have or have ever had a slow or irregular heartbeat; low levels of potassium in your blood; or heart, kidney, or liver disease.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking quinine, call your doctor.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking quinine.
• tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do IF I FORGET to take a dose?

Take the missed dose as soon as you remember it. However, if it has been more than 4 hours since the time you should have taken the missed dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What SIDE EFFECTS can this medicine cause?

Quinine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• nausea
• restlessness
• difficulty hearing or ringing in the ears
• confusion
• nervousness

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

• rash
• hives
• itching
• flushing
• hoarseness
• difficulty breathing or swallowing
• swelling of the face, throat, lips, eyes, hands, feet, ankles or lower legs
• fever
• blisters
• stomach pain
• vomiting
• diarrhea
• blurriness or changes in color vision
• inability to hear or see
• faintness
• easy bruising
• purple, brown, or red spots on the skin
• unusual bleeding
• blood in the urine
• dark or tarry stools
• nosebleeds
• bleeding gums
• sore throat
• fast or irregular heartbeat
• chest pain
• weakness
• sweating
• dizziness

Quinine may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Do not refrigerate or freeze the medication.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (https://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. https://www.upandaway.org

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include:

• blurriness or changes in color vision
• symptoms of low blood sugar
• changes in heartbeat
• headache
• nausea
• vomiting
• stomach pain
• diarrhea
• ringing in the ears or difficulty hearing
• seizures
• slow or difficult breathing

What OTHER INFORMATION should I know?

Keep all appointments with your doctor.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking quinine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™. © Copyright, 2024. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: June 15, 2017.